Pharmacology MCQ for GPAT or other COMPETITIVE exams-[PART-1]

                                      

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1.Actophotometer is basically used for the evaluation

of—

1- Analgesic 

2- Antipyretic

3- Antidepressant

4- Inflammation

Ans:-1

2.Which of the following step is essential for the

conversion of a nonpolar substance to polar one for

the excretion.

1- Absorption

2- Distribution

3- Metabolism 

4- Elimination

Ans:-3

3.Experimental animal suitable for the study of

angiogenesis

1- Rat

2- Mice

3- Gebril

4- Zebra Fish

Ans:-4

4.Plasma protein binding of the drug may

1- Reduce its availability 

2- Increase its availability

3- Both of the above

4- None of the above

Ans:-1

5.Seven-(pass)—transmembrane domain receptors, 7TM

receptors, heptahelical receptors, the serpentine

receptor is another name of-

1- GPCR 

2- Ligand-gated ion channel

3-GABA receptors

4- Glycin receptor

Ans:-1

6.Which o the following is/are criteria for any chemical

to be a neurotransmitter-

1- Should available at presynaptic nerve

2- Should release from the presynaptic nerve ending

3- Must bind to postsynaptic receptors

4- All of the above

Ans:-4

7.Treatment of methanol poisoning is-

1-Ethanol 

2- Wood spirit

3- Terbutaline

4- All of the above

Ans:-1

8.To increase the bioavailability we have to increase—

1- Surface area

2- Particle size

3- Solubility

4- Both 1 and 3

Ans:-4

9.Availability of insulin may also be a reason for

diabetes, this is due to-

1- Upregulation

2- Downregulation

3- Resistance

4- Both 1 and 3

Ans:-2

10.Hot Plate method is used to evaluate-

1-Analgesic activity 

2- Inflammatory activity

3- CNS activity (Psychopharmacology)

4- None of the above

Ans:-1

11.Organ bath is basically used for the assessment of-

1-Bioassay- Invitro 

2- Bioassay- Invlvo

3- Bioassay in silico

4- All of the above

Ans:-1

12.Why we can't give dopamine as such in treatment of

Parkinson disease

1- Due to the inability to cross BBB

2- Due to the metabolism of Dopamine in Brain

3- Both 1 and 2 

4- None of the above

Ans:-3

13.Which of the following is not a mechanism of action

for antidepressant drugs

1- SSRI

2- MAO Inhibitor

3- Serotonin/Norepinephrine reuptake inhibitors

4- Blocking of sodium and chlorine channel

Ans:-4

14.The cup-plate method is an example of-

1- Biological evaluation method 

2- Chemical Method of evaluation

3- Both 1 and 2

4- None of the above

Ans:-1

15.Which of the following is not a type of biological

barrier

1- BBB

2- BPB

3- BTB

4- LLL

Ans:-4

16.Bioavailability depends on-

1- Rate of absorption

2- Extent of absorption

3- Both rate and extent of absorption 

4- Based on pharmacogenomic criteria

Ans:-3

17.Diabetes is an example of-

1- Metabolic disorder

2-Genetic factor is also possible

3- Downregulation of Insulin receptors

4-All of the above

Ans:-4

18.Which of the following are common side effect and

limitation of antibiotics

1- Resistance

2- Disturbance of microbial flora in GIT

3- Both 1 and 2 

4- Potentiation of activity

Ans:-3

19.Treatment of Parkinson disease by Ievodopa and

carbidopa is best? on the principle of—

1- Replacement

2- Stimulation

3- Depression

4- All of the above

Ans:-1

20.Which of the following option is true about drug action

1- Drug is sufficient

2- Receptor is sufficient

3- Drug and receptor complex is essential 

4- All of the above

Ans:-3

21.Which source of drug is rarely utilized

1- Marine

2-Animal

3-Plant

4-Microbial

Ans:-1

22.Neuromuscular blocking agents act at

l- Muscarinic receptors

2- Nicotinic Receptors 

3- Dopamine receptors

4- All of the above

Ans:-2

23.Cholinergic drugs may act by-

1- Reducing the cholinesterase

2- Increasing the availability of acetylcholine at

postsynaptic receptors

3- Both 

4- None of the above

Ans:-3

24.Which o the following is listed under monoamine

l- Serotonin

2- Norepinephrine

3- Dopamine

4- All of the above 

Ans:-4

25.Receptors are-

1- Micromolecule

2- Available at intra and extracellular

3- Macromolecule

4- Both 2 and 3 

Ans:-4

26.Myasthenia Gravis is an

1- Neuron disease 

2- Bacterial disease

3- Metabolic Disease

4- All of the above

Ans:-1

27.Sickle cell anemia is due to

1- Nonsense mutation

2- Missense mutation 

3- Chromosomal muation

4- Silent mutation

Ans:-2

28.Hormone which stimulate Glycogenesis

1- Glucagon

2- Insulin 

3- Epinephrine

4- Glucocorticoid

Ans:-2

29.Which of following is Anti- Herpes drug

1- Ritonavir

2- Oseltamavir

3- Zanamivir

4- Acyclovir 

Ans:-4