Pharmacology MCQ for GPAT or other COMPETITIVE exams -[PART-2]

                         

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1.Example of phase 01 metabolism-

1- Chloramphenicol 

2- Halothane 

3- Procaine 

4- Allof the above 

Ans:-4

 

2.Find the sites which are "Difficult to enter" for drugs-

1- CSF

2- Occular fluid

3- Lymph

4- All of the above 

Ans:-4

3.Ceasing of thiopental sodium activity for 5-15 minutes

is an example of (Most Specific)

1- Distribution

2- Absorption

3- Metabolism

4- Re-Distribution 

Ans:-4

4.Emetine has a maximum affinity for which of the

following tissue-

1- Adipose tissue

2- Muscle

3- Bone

4- Thyroid

Ans:-2

5.Which of the following drug has a special affinity for

retina

1- Thiopentone sodium

2- Emetine

3- Chloroquine 

4- lodine

Ans:-3

6.The effect of protein binding of the drug on half-life

is-

1- Prolonged 

2- Short

3- Disturbed

4- None of the above

Ans:-1

7.Which of the following drug has 0% affinity for plasma Protein binding-

1- Ethosuximide 

2- Lithium 

3- Warfarin 

4- Both 1and2 

Ans:-4

8.Acidic drugs bind with - 

1- Albumin 

2- Alpha-acid glycoprotein 

3- Tubulin

4- All of the above

Ans:-2

9.Which of the following drug has been removed from

the baned fixed drug combination list-

1-Saridon

2-paracetamol

3-Nimesulide

4- None of the above

Ans:-1

10.Erectile dysfunction may be a side effect of-

1- Beta-blocker 

2- Antimicrobial 

3- Diuretic 

4- Antimalarial drugs 

Ans:-1

11.Type III allergic reaction is also known as-

1- Arthus reaction 

2- Cytolytic reaction

3- Delayed reaction

4- Anaphylactic reaction

Ans:-1

12.Which of the following drug need to be given on an

empty stomach

1- Rifampicin 

2- Roxithromycin

3- Both

4- None

Ans:-1

13.In pharmacology "P-Drug" is known as-

1-Profitable drug

2- Preferred drug

3- Personal drug

4- Plasma free drug

Ans:-3

14.Which type of bacteria are not susceptible to

metronidazole

1- Aerobic 

2- Anaerobic

3- Thermophilic

4- All of the above

Ans:-1

15.Which of the following is the unutilized (in comparison

to others) source of drug

1- Mineral

2- Marine

3- Plant

4- Animal

Ans:-2

16.GABA receptor is associated with (Entry of)

1- Sodium lons

2- Pottasium lons

3- Chloride lons 

4- Calcium lons

Ans:-3

17.Penicillin id eliminated through urine in which of the

following steps-

1- Filtration

2- Tubular Reabsorption

3- Tubular Secretion 

4- All of the above

Ans:-3

18.Viral is mostly grown in

1- Livingcell 

2- Dead plants

3- Agar culture plate

4- Broth culture

Ans:-1

19.Which of the following are the consequences of

metabolism

1- Activation of inactive drug

2- Inactivation of active drug

3- Active metabolite from active drugs

4- Allof the above 

Ans:-4

20.The microsomal enzyme is produced by

1- Microsome of liver 

2- Mitochondria of liver

3- Both

4- Kidney

Ans:-1

21.The therapeutic index is a ratio of-

1- ED50 and LD 50

2-LD50 and ED50 

3- LD50 and TD50

4- Both 2 and 3

Ans:-2

22.Phagocytosis is -

1-Eating process

2- Drinking process

3- Both

4- None

Ans:-1

23.Deep vein thrombosis with oral contraceptive is an

example of (Most suitable)

1- Idiosyncratic reaction

2- ADR

3- Contraindication

4- None of the above

Ans:-1

24.Grapefruit may-

1- Induce microsomal enzymes

2- Inhibit Microsomal enzymes 

3- Affect Absorption of drugs

4- None of the above

Ans:-2

25.Bulaquine is developed in India for-

1- Malaria 

2- Jaundice

3- TB

4- Ulcer

Ans:-1

26.Penicillin V is

1- Base resistance

2- Acid resistance 

3- Both

4- None

Ans:-2

27.H3 receptor is located at-

1- Brain 

2- CD4 Cells

3- Stomach

4- None

Ans:-1

28.Erythropoietin is produced in-

1- Kidney 

2- Liver

3- Brain

4- All

Ans:-1

29.Primaquine is effective against all forms of the

malarial parasite except-

1-Plasmolytic form

2- Both

3-Erythrocytic form

4- None of the above

Ans:-3

30.Who is the father of modern chemotherapy

1- Adverd Jenner

2- Louise Pasture

3- Paul Ehrlich 

4- Jhon waxom

Ans:-3

31.Enzyme inhibition can ......the duration of action of

drugs

1- Increase 

2- Decrease

3- No change

4- No role of the enzyme on metabolism

Ans:-1

   

32.Methyldopa is transported via-

1- Active Transport 

2- Passive Transport

3- Filtration

4- Endocytosis

Ans:-1

33.A condition at which a patient required excess

concentration of drug to achieve the same effect

which he/she used to get is called-

1- Intolerance

2- Tolerance

3- Cross tolerance

4- All of the above

Ans:-2

34.The action of Insulin is based on which principle

1-Replacement 

2- Stimulant

3- Depressant

4- Irritant

Ans:-1

35.Paracetamol and Nimesulide combination could be an

example of-

1- Additive effect 

2- Superadditive effect

3- Antagonistic effect

4- None of the above

Ans:-1

36.Which of the following is not correct for the receptor

1- Micromolecule 

2- Macromolecule

3- Based on lock and key theory

4- They don't have their own pharmacological actions

Ans:-1

37.In the case of drug addiction threshold of following is

changed-

1- Dopamine 

2- Acetylcholine

3- Histamine

4- None

Ans:-1

38.Steroidal hormone follow which phase of metabolism

1- Phase -I

2- Phase-ll 

3- None

4- Both

Ans:-2

39.Range (Distance) between MEC and MSC is known

as-

1- Therapeutic index

2- Therapeutic Window

3- ED50

4- None of the above

Ans:-2

40.Mechanism of drug action is studied under-

1- Pharmacokinetic

2- Pharmacodynamic 

3- Both

4- Pharmacogenomics

Ans:-2

41.Transmembrane enzyme-linked receptors are related

with-

1- Peptidal Hormone

2- Autophosphorylation

3- Phosphorylation of substrate protein

4- Allof the above

Ans:-4

42. Barbiturates are derivatives of-

1-Ethylalchol

2-Oxazepam

3-Urea

4-Opium

Ans:-3

                                                                                                                                                                      

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